It is also by far the most exciting right now, with the two sides arguably the best in world football at the moment.
Last season, Liverpool and City played out one of the greatest Premier League games of all time at the Etihad.
Pep Guardiola's side ran out 2-1 winners thanks to goals from Sergio Aguero and Leroy Sane, with a strike from Roberto Firmino sandwiched in-between.
The intensity of the game and quality of play was a credit to both teams and their rivalry will only intensify in 2019/20.
- Sadio Mane's transfer value has skyrocketed
- Liverpool made the most TV money in 2018/19
- Check out our new GIVEMESPORT homepage
But on this day two years ago, Liverpool were on the receiving end of City's brutal excellence.
Jurgen Klopp's side were beaten 5-0 at the Etihad, with goals coming from Aguero, Gabriel Jesus (2) and Sane (2).
Sadio Mane's red card in the first half obviously had a significant impact on the game, but the gulf in class between the two teams was evident.
But fast forward two years and the gap has well and truly been closed.
Klopp and Liverpool's hierarchy have brought in the likes of Virgil van Dijk, Alisson Becker, Andy Robertson and Fabinho to remedy Liverpool's leaky defence.
It really was a watershed moment for the club, they knew they couldn't challenge the elite with the likes of Alberto Moreno trying to thwart the world's best attackers.
And even in attack, things have changed drastically.
Mohamed Salah started the 5-0 loss, but was taken off at half-time after missing a number of chances.
Now, the Egyptian is arguably the finest goalscorer in the league and the thought of him being substituted at the break in any big game is almost laughable.
Two years is a long, long time in football and Liverpool's transformation over that time period is proof that if you really want to change your fortunes, you can do just that - as long as you have a little bit of spare cash...News Now - Sport News