The Portuguese icon will all but certainly play a significant part in the Red Devils' group game away versus Young Boys.
Big things will be expected of Ronaldo in the Champions League this season, as he's made the competition his own personal playground over the past decade or so.
At Real Madrid, the 36-year-old lifted the trophy on four occasions in the space of just five years.
He's also the competition's all-time leading scorer with 134 goals in 176 appearances.
As well as being the most prolific goal-getter, Ronaldo holds the record for the most assists in Champions League history with 42.
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That means he averages one goal contribution per game in the world's toughest club competition, which is absolutely outrageous.
What makes Ronaldo's Champions League numbers even more incredible is the fact that he's been ridiculously efficient in the knockout stage.
Amazingly, the adonis-like forward has contributed to 77 goals in games played after the group stage, which is more than double that of the man with the third-most.
Don't believe us? Well, take a look at the brilliant graphic from Reddit that proves just that below...
The 20 players with the most G+A in the Champions League knockout stage
Cristiano, we are not worthy.
Both the United man and Lionel Messi are streets ahead of the rest, with Thomas Muller making up the rest of the top three.
It's a 20-man list that is full of legendary figures and perhaps the most surprising name on it is that of Barcelona legend, Dani Alves.
Despite primarily operating as a defender, the Brazilian still contributed to 18 goals in the knockout stage of the Champions League - something that almost beggars belief.
Wayne Rooney leads the way among players who primarily played for a Premier League team in the competition, with Frank Lampard taking second place in that regard.
Well played, lads.