Fury, 33, floored Wilder twice and stopped him in the seventh in their rematch following the controversial draw in their first meeting.
The 33-year-old is expected to weigh in considerably more than Wilder, who is blessed with ferocious speed and power and will be attempting to win back his WBC heavyweight title.
These well-known faces from the world of the UFC have had their say on who they think will come out on top.
Tom Aspinall - Fury win
Tom Aspinall knows exactly where his loyalties lie, having spent many hours sparring with The Gypsy King.
Fury blew away Wilder in seven rounds last year to claim the WBC heavyweight title, and the Team Kaobon star has backed his fellow Brit to go one better this weekend.
"It's inevitable, isn't it? Tyson will run straight through him again," Aspinall told BT Sport.
"Quicker this time I reckon, I reckon he'll do it within six."
Daniel Cormier - Undecided
Former two-weight world champion Daniel Cormier is concerned that Fury might be too big for Wilder, but refused to rule anything out.
Speaking to ESPN, Cormier explained: “Deontay is not a big guy. Deontay is only about 220lbs. So, Tyson Fury is massive.
"Stay big, press him like you did last time, try to remind him why the fight ended in the way that it did last time.
"But, we know that the Bronze Bomber, has that right hand, and that thing is dynamite.
"If he can land it, he can ruin all the plans [of Fury].
"If I am betting today, I have to bet against Deontay Wilder…
"I just don’t know man, I think the size [of Fury] is too much of an issue for him.”
Molly McCann - Fury win
Despite acknowledging Wilder's unrivalled knockout power, Molly McCann echoed Aspinall's comments that Fury will have wrapped it up by the time the fight reaches the halfway point on the night.
"[Tyson] within six, because they know how hard each other hits, they've got a feel for each other's timing, and Tyson's broke him twice," she said when quizzed by BT Sport.
"The first fight he broke him when he got up, second fight he broke him because he just made him look like a child in there.
"I was going to say six, great minds think alike you know.
"It's still a fight though, he's [Wilder] still dangerous with that big clubbing backhand."
Khabib Nurmagomedov - Fury win
The retired lightweight who went 13-0 in the UFC and 29-0 overall who's now enjoying his retirement believes there is a case to be made for Fury as the top fighter by being the king at 201 pounds.
When asked to name his pound-for-pound king, he told ESNews: "Right now? I truly believe Tyson Fury is the best.
"Heavyweight and undefeated and he beat everybody.
"Like very close, like Canelo [Alvarez], [Oleksandr] Usyk, [Terence] Crawford, like all these guys very close.
"Like just my opinion like top like Tyson Fury right now.
“I really want to see Usyk vs Fury. It’s gonna be a very good fight.
"He [Usyk] has very good skill and technique, Tyson Fury too.
“He is not like other heavyweights, more technique, his footwork is very good, his conditioning is very good, I really wanna watch Usyk against Fury.”
Paddy Pimblett - Fury win
Meanwhile Paddy Pimblett has also made a similarly bold prediction, telling BT Sport: "I'm going to go within four. Tyson's going to do him in four. I'm switching it up.
"As you said, he's already broken him mentally and physically, he's got him."
Dana White - Fury win
Fury has also received the backing of UFC president Dana White.
"I just think Fury's too good, I think Fury's got that number," White said via TheMacLife.